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This actor was told he had Alzheimer's, now he's performing a one-man show Image caption, Peter Marinker, who was diagnosed with Alzheimer's disease two years ago, began dress rehearsals for the Beckett play Krapp's Last Tape in June For four days running, Peter Marinker had arrived at rehearsals that were not even taking place. Dementia had muddled the dates in his mind. Yet he is now preparing to do something most actors would find daunting even with perfect recall: performing a much-loved Samuel Beckett play alone on a London stage. Marinker, 85, is best known for his voice work: from radio plays and video games to big-budget films like Labyrinth and Paddington in Peru. On camera he was the adviser to the US president in Love Actually and one of the airline passengers in the drama United 93.

Follow this section to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens. Follow this tag to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens.

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A Qatar-based professor has pioneered a non-invasive eye scan to detect neurodegenerative diseases years before symptoms appear. The technology uses AI to analyse the eye and can identify early signs of dementia, Parkinson's disease, and other diseases within minutes. Church leaders killed in latest ethnic violence in India's Manipur

Selection bias arises when the probability that an observation enters a dataset depends on variables related to the quantities of interest, leading to systematic distortions in estimation and uncertainty quantification. For example, in epidemiological or survey settings, individuals with certain outcomes may be more likely to be included, resulting in biased prevalence estimates with potentially substantial downstream impact. Classical corrections, such as inverse-probability weighting or explicit likelihood-based models of the selection process, rely on tractable likelihoods, which limits their applicability in complex stochastic models with latent dynamics or high-dimensional structure. Simulation-based inference enables Bayesian analysis without tractable likelihoods but typically assumes missingness at random and thus fails when selection depends on unobserved outcomes or covariates. Here, we develop a bias-aware simulation-based inference framework that explicitly incorporates selection into neural posterior estimation. By embedding the selection mechanism directly into the generative simulator, the approach enables amortized Bayesian inference without requiring tractable likelihoods. This recasting of selection bias as part of the simulation process allows us to both obtain debiased estimates and explicitly test for the presence of bias. The framework integrates diagnostics to detect discrepancies between simulated and observed data and to assess posterior calibration. The method recovers well-calibrated posterior distributions across three statistical applications with diverse selection mechanisms, including settings in which likelihood-based approaches yield biased estimates. These results recast the correction of selection bias as a simulation problem and establish simulation-based inference as a practical and testable strategy for parameter estimation under selection bias.

Research shows that people who sleep poorly tend to have brain age that is older than their actual age. Chronic inflammation in the body caused by poor sleep likely plays a part. While the link between poor sleep and dementia has long been known, it was unclear whether poor sleep habits could cause dementia or whether poor sleep was an early symptom of dementia. However, new research has revealed that sleep quality may have a direct impact on the rate at which the brain ages . Our findings provide evidence that poor sleep may contribute to accelerated brain aging, explains Abigail Dove, a neuroepidemiologist at the Karolinska Institute in Sweden, and point to inflammation as one of the underlying mechanisms.

Things to Do in L.A. Tap to enable a layout that focuses on the article. 'Memory manipulation is inevitable': How rewriting memory in the lab might one day heal humans Professor and neuroscientist Steve Ramirez, shown working with brain samples, is exploring the science of memory manipulation. This is read by an automated voice. Please report any issues or inconsistencies here . Scientists have found that memories are not static records but dynamic processes that change the brain's wiring each time they are recalled.

We find a surprising connection between multitask learning and robustness to neuron failures. Our experiments show that bilingual language models retain higher performance under various neuron perturbations, such as random deletions, magnitude pruning and weight noise. Our study is motivated by research in cognitive science showing that symptoms of dementia and cognitive decline appear later in bilingual speakers compared to monolingual patients with similar brain damage, a phenomenon called bilingual cognitive reserve. Our language model experiments replicate this phenomenon on bilingual GPT-2 and other models.We provide a theoretical justification of this robustness by mathematically analyzing linear representation learning and showing that multitasking creates more robust representations.