Research shows that people who sleep poorly tend to have brain age that is older than their actual age. Chronic inflammation in the body caused by poor sleep likely plays a part. While the link between poor sleep and dementia has long been known, it was unclear whether poor sleep habits could cause dementia or whether poor sleep was an early symptom of dementia. However, new research has revealed that sleep quality may have a direct impact on the rate at which the brain ages . Our findings provide evidence that poor sleep may contribute to accelerated brain aging, explains Abigail Dove, a neuroepidemiologist at the Karolinska Institute in Sweden, and point to inflammation as one of the underlying mechanisms.

Things to Do in L.A. Tap to enable a layout that focuses on the article. 'Memory manipulation is inevitable': How rewriting memory in the lab might one day heal humans Professor and neuroscientist Steve Ramirez, shown working with brain samples, is exploring the science of memory manipulation. This is read by an automated voice. Please report any issues or inconsistencies here . Scientists have found that memories are not static records but dynamic processes that change the brain's wiring each time they are recalled.

We find a surprising connection between multitask learning and robustness to neuron failures. Our experiments show that bilingual language models retain higher performance under various neuron perturbations, such as random deletions, magnitude pruning and weight noise. Our study is motivated by research in cognitive science showing that symptoms of dementia and cognitive decline appear later in bilingual speakers compared to monolingual patients with similar brain damage, a phenomenon called bilingual cognitive reserve. Our language model experiments replicate this phenomenon on bilingual GPT-2 and other models.We provide a theoretical justification of this robustness by mathematically analyzing linear representation learning and showing that multitasking creates more robust representations.

Breakthroughs, discoveries, and DIY tips sent every weekday. It's been found in ancient human feces . The U.S. government stored 6.4 metric tons of it in mountains . And a big hunk of it played a major role in a presidential farewell party . While too much of the popular dairy product can spell tummy troubles and high cholesterol for some, new research suggests that eating more high-fat cheese and cream could be linked to a lower risk of developing dementia .

Japan is facing a dementia crisis - can technology help? Last year, more than 18,000 older people living with dementia left their homes and wandered off in Japan. Almost 500 were later found dead. Police say such cases have doubled since 2012. Elderly people aged 65 and over now make up nearly 30% of Japan's population - the second-highest proportion in the world after Monaco, according to the World Bank.

Reinforcement Learning (RL) faces significant challenges in adaptive healthcare interventions, such as dementia care, where data is scarce, decisions require interpretability, and underlying patient-state dynamic are complex and causal in nature. In this work, we present a novel framework called Causal structure-aware Reinforcement Learning (CRL) that explicitly integrates causal discovery and reasoning into policy optimization. This method enables an agent to learn and exploit a directed acyclic graph (DAG) that describes the causal dependencies between human behavioral states and robot actions, facilitating more efficient, interpretable, and robust decision-making. We validate our approach in a simulated robot-assisted cognitive care scenario, where the agent interacts with a virtual patient exhibiting dynamic emotional, cognitive, and engagement states. The experimental results show that CRL agents outperform conventional model-free RL baselines by achieving higher cumulative rewards, maintaining desirable patient states more consistently, and exhibiting interpretable, clinically-aligned behavior. We further demonstrate that CRL's performance advantage remains robust across different weighting strategies and hyperparameter settings. In addition, we demonstrate a lightweight LLM-based deployment: a fixed policy is embedded into a system prompt that maps inferred states to actions, producing consistent, supportive dialogue without LLM finetuning. Our work illustrates the promise of causal reinforcement learning for human-robot interaction applications, where interpretability, adaptiveness, and data efficiency are paramount.

We target passive dementia screening from short camera-facing talking head video, developing a facial temporal micro dynamics analysis for language free detection of early neuro cognitive change. This enables unscripted, in the wild video analysis at scale to capture natural facial behaviors, transferrable across devices, topics, and cultures without active intervention by clinicians or researchers during recording. Most existing resources prioritize speech or scripted interviews, limiting use outside clinics and coupling predictions to language and transcription. In contrast, we identify and analyze whether temporal facial kinematics, including blink dynamics, small mouth jaw motions, gaze variability, and subtle head adjustments, are sufficient for dementia screening without speech or text. By stabilizing facial signals, we convert these micro movements into interpretable facial microdynamic time series, smooth them, and summarize short windows into compact clip level statistics for screening. Each window is encoded by its activity mix (the relative share of motion across streams), thus the predictor analyzes the distribution of motion across streams rather than its magnitude, making per channel effects transparent. We also introduce YT DemTalk, a new dataset curated from publicly available, in the wild camera facing videos. It contains 300 clips (150 with self reported dementia, 150 controls) to test our model and offer a first benchmarking of the corpus. On YT DemTalk, ablations identify gaze lability and mouth/jaw dynamics as the most informative cues, and light weighted shallow classifiers could attain a dementia prediction performance of (AUROC) 0.953, 0.961 Average Precision (AP), 0.851 F1-score, and 0.857 accuracy.

People living with dementia (PLwD) often show gradual shifts in how they communicate, becoming less expressive, more repetitive, or drifting off-topic in subtle ways. While caregivers may notice these changes informally, most computational tools are not designed to track such behavioral drift over time. This paper introduces PersonaDrift, a synthetic benchmark designed to evaluate machine learning and statistical methods for detecting progressive changes in daily communication, focusing on user responses to a digital reminder system. PersonaDrift simulates 60-day interaction logs for synthetic users modeled after real PLwD, based on interviews with caregivers. These caregiver-informed personas vary in tone, modality, and communication habits, enabling realistic diversity in behavior. The benchmark focuses on two forms of longitudinal change that caregivers highlighted as particularly salient: flattened sentiment (reduced emotional tone and verbosity) and off-topic replies (semantic drift). These changes are injected progressively at different rates to emulate naturalistic cognitive trajectories, and the framework is designed to be extensible to additional behaviors in future use cases. To explore this novel application space, we evaluate several anomaly detection approaches, unsupervised statistical methods (CUSUM, EWMA, One-Class SVM), sequence models using contextual embeddings (GRU + BERT), and supervised classifiers in both generalized and personalized settings. Preliminary results show that flattened sentiment can often be detected with simple statistical models in users with low baseline variability, while detecting semantic drift requires temporal modeling and personalized baselines. Across both tasks, personalized classifiers consistently outperform generalized ones, highlighting the importance of individual behavioral context.

Background and Objectives: This paper focuses on using AI to assess the cognitive function of older adults with mild cognitive impairment or mild dementia using physiological data provided by a wearable device. Cognitive screening tools are disruptive, time-consuming, and only capture brief snapshots of activity. Wearable sensors offer an attractive alternative by continuously monitoring physiological signals. This study investigated whether physiological data can accurately predict scores on established cognitive tests. Research Design and Methods: We recorded physiological signals from 23 older adults completing three NIH Toolbox Cognitive Battery tests, which assess working memory, processing speed, and attention. The Empatica EmbracePlus, a wearable device, measured blood volume pulse, skin conductance, temperature, and movement. Statistical features were extracted using wavelet-based and segmentation methods. We then applied supervised learning and validated predictions via cross-validation, hold-out testing, and bootstrapping. Results: Our models showed strong performance with Spearman's ρof 0.73-0.82 and mean absolute errors of 0.14-0.16, significantly outperforming a naive mean predictor. Sensor roles varied: heart-related signals combined with movement and temperature best predicted working memory, movement paired with skin conductance was most informative for processing speed, and heart in tandem with skin conductance worked best for attention. Discussion and Implications: These findings suggest that wearable sensors paired with AI tools such as supervised learning and feature engineering can noninvasively track specific cognitive functions in older adults, enabling continuous monitoring. Our study demonstrates how AI can be leveraged when the data sample is small. This approach may support remote assessments and facilitate clinical interventions.

Lexical alignment, where speakers start to use similar words across conversation, is known to contribute to successful communication. However, its implementation in conversational agents remains underexplored, particularly considering the recent advancements in large language models (LLMs). As a first step towards enabling lexical alignment in human-agent dialogue, this study draws on strategies for personalising conversational agents and investigates the construction of stable, personalised lexical profiles as a basis for lexical alignment. Specifically, we varied the amounts of transcribed spoken data used for construction as well as the number of items included in the profiles per part-of-speech (POS) category and evaluated profile performance across time using recall, coverage, and cosine similarity metrics. It was shown that smaller and more compact profiles, created after 10 min of transcribed speech containing 5 items for adjectives, 5 items for conjunctions, and 10 items for adverbs, nouns, pronouns, and verbs each, offered the best balance in both performance and data efficiency. In conclusion, this study offers practical insights into constructing stable, personalised lexical profiles, taking into account minimal data requirements, serving as a foundational step toward lexical alignment strategies in conversational agents.